Abstract：[Obj ective]To explore the efficacy of nimotuzumab combined with intensity-modulated radiothera-py(IMRT)and GP regimen(gemcitabine plus cisplatin)in the treatment of locally recurrent nasopharyngeal carci-noma(NPC).[Methods]A total of 7 1 patients with locally recurrent NPC in our hospital were randomly divided into observation group(n=35)and control group(n=36).All patients received IMRT and GP regimen(gemcit-abine plus cisplatin).The observation group was intravenously administered nimotuzumab 100mg weekly for 6~7 weeks before radiotherapy.The efficacy of two groups was observed and compared.[Results]The complete re-sponse(CR)of primary lesion at 3 months after treatment and local control rate at 1 and 2 years after treatment in the observation group were 65.7%,91.4% and 82.9% respectively,while those in the control group were 41.7%,72.2% and 61.1% respectively,and there was significant difference between two groups(P <0.05). The distant metastasis-free survival rate in the observation group at 1 and 2 years after treatment were 88.6% and 77.1% respectively which were higher than those in the control group(75.0% and 66.6%,respectively),but there was no significant difference between two groups(P>0.05).There was no significant difference in the inci-dence of short-term and long-term toxic side effects between two groups.[Conclusion]Nimotuzumab combined with IMRT and GP regimen can improve the CR rate and local control rate of locally recurrent NPC.
引用本文:
郭戈杨%罗英%杨晓琳%李宇. 尼妥珠单抗联合调强放疗及 GP 方案治疗局部复发鼻咽癌的临床观察[J]. 医学临床研究, 2014, 31(6): 1086-1091.
2014, Vol. 31 
