Abstract：[Obj ective]To explore the tolerance and clinical efficacy of early parenteral nutrition through pe-ripheral central venous catheter in very low birth weight infants(VLBWIs).[Methods]Totally 98 VLBWIs who were not tolerant to full enteral nutrition in neonatology department of our hospital were randomly divided into two groups.The observation group(n=49)received parenteral nutrition through peripheral central venous catheter within 2h after birth,while the routine treatment group(n=49)received traditional venous nutrition scheme at 48h after birth.Calories and protein in two groups during hospitalization were calculated.Blood glucose,head circumference and body weight were monitored.Blood samples were collected to determine biochemical indexes. All the results were statistically analyzed.[Results]Calories and protein intake in observation group at 3 days after birth reached the intake standard of premature infant,and there was significant difference between observation group and routine treatment group(P<0.01).There was no significant difference in calories and protein intake at 9 days after birth between observation group and control group(P>0.05).The accumulation lose of calories and protein in observation group at 3,9 and 21 days after birth were obviously lower than those in routine treatment group,and there was significant difference(P<0.01).The time to regain birth weight in observation group was obviously shorter than that in routine treatment group,and there was significant difference(P <0.01).The growth of head circumference and body height in observation group were faster than those in routine treatment group,and there was significant difference(P <0.05).There was no significant difference in the incidence of complications between two groups.[Conclusion]VLBWIs have good tolerance to early parenteral nutrition.The weight gain is fast,and the time to reach full enteral feeding is shortened,and parenteral nutrition-related compli-cations are not increased.
2014, Vol. 31 
