Abstract：[Obj ective]To explore the relationship between epidermal growth factor receptor tyrosine kinase domain (EGFR-TKD)mutation and radiosensitivity in patients with lung adenocarcinoma.[Methods]A total of 3 6 lung adeno-carcinoma patients with EGFR-TKD mutation were selected as the observation group.A total of 24 patients without EG-FR-TKD mutation were selected as the control group.Three-dimensional conformal radiotherapy was performed in prima-ry lung lesions of patients in 2 groups.Chest CT reexamination was performed 1 month after radiotherapy and used to e-valuate the short-term efficacy.[Results]All patients completed the treatment smoothly.In the observation group,1 0 patients were complete remission(CR),and 24 patients were partial remission(PR),and 2 patients were stable,and no one was developed,and the short-term total effective rate(CR+PR)was 94.4%.In the control group,7 patients were complete remission(CR),and 1 0 patients were partial remission(PR),and 6 patients were stable,and 1 patient was de-veloped,and the total short-term effective rate was 70.8%.There was significant difference in the short-term efficacy be-tween two groups(P<0.05).[Conclusion]Lung adenocarcinoma patients with EGFR-TKD mutation have better short-term efficacy.It suggests that EGFR-TKD mutation is an important indicator of predicting radiosensitivity.
基金资助:长沙市科技局科技计划一般项目(计划编号K1207029-31)
引用本文:
苏加利%朱道奇%杨妤. 肺腺癌患者表皮生长因子受体酪氨酸激酶结构域突变与放射敏感性的关系[J]. 医学临床研究, 2014, 31(6): 1062-1064.
SU Jia-li%ZHU Dao-qi%YANGYu. Relationship Between Epidermal Growth Factor Receptor Tyrosine Kinase Domain Mutation and Radiosensitivity in Patients with Lung Adenocarcinoma. 医学临床研究, 2014, 31(6): 1062-1064.
2014, Vol. 31 
