Analysis of the Relationship Between Serum Monocyte Chemoattractant Protein-1 Level and the Stability of Carotid Atherosclerotic Plaque in Elderly Patients with Acute Cerebral Infarction
Abstract：[Objective]To analyze the association between serum monocyte chemoattractant protein-1 (MCP-1)concentration and the stability of carotid atherosclerotic plaque in elderly patients with acute cerebral infarction among Han people of Hunan province.[Methods]Totally 154 elderly patients with acute cerebral infarction and 80 healthy volunteers were recruited in our hospital from Dec.2010 to May 2013.Enzyme-linked immunosorbent assay(ELISA)was used to measure serum MCP-1 level in all subj ects.Carotid intima-media thickness(IMT)were measured color Doppler ultrasonography.According to IMT,all patients were di-vided into non-plaque group(n=32),stable plaque group(n=49)and unstable plaque group(n=73).The difference in serum MCP-1 level among groups was analyzed.The relationship between serum MCP-1 level and the stability of carotid atherosclerotic plaque was also analyzed.[Results]Serum MCP-1 level in unstable plaque group(113.64±48.04 pg/mL)was higher than that in stable plaque group(61.78±22.34pg/mL),and that in stable plaque group was higher than that in non-plaque group(44.84±25.26pg/mL),and there was significant difference between two groups(F=80.06,P<0.01).There was no significant difference in ser-um MCP-1 level between non-plaque group and control group.Serum MCP-1 level was correlated with the sta-bility of carotid atherosclerotic plaque(P >0.05).[Conclusion]Serum MCP-1 level may be associated with the stability of carotid atherosclerotic plaque in elderly patients with acute cerebral infarction among Han peo- #br# ple of Hunan province.
基金资助:国家自然科学基金青年科学基金项目资助(项目编号81301576)
引用本文:
何丹%陈婵娟%柳四新. 人血清单核细胞趋化蛋白-1表达水平与老年急性脑梗死患者颈动脉粥样硬化斑块稳定性的相关性研究[J]. 医学临床研究, 2014, 31(6): 1053-1058.
HE Dan%CHEN Chan-juan%LIU Si-Xin. Analysis of the Relationship Between Serum Monocyte Chemoattractant Protein-1 Level and the Stability of Carotid Atherosclerotic Plaque in Elderly Patients with Acute Cerebral Infarction. 医学临床研究, 2014, 31(6): 1053-1058.
2014, Vol. 31 
