Abstract：[Objective]To explore the correlation between p21 gene rs1059234 polymorphisms and endome-trial cancer in Han women from northeast China.[Methods]The sequencing and PCR-restriction fragment length polymorphism(PCR-RFLP)were used for the genotyping of p21 gene rs1059234 in peripheral blood DNA of 263 patients with endometrial cancer(observation group)and 315 healthy subjects(control group). The correlation between the genotypes and endometrial cancer was analyzed.[Results]Compared with control group,the C allele frequency of rs1059234 in observation group was increased obviously(P=0.039),and the CC genotype frequency of rs1059234 in observation group had obvious increasing trend(0.335 vs.0.219,P=0.045).The CC genotype could increase the risk of endometrial cancer(OR=1.589,95%CI:1.010~2.502). After correction with regression analysis,the CC genotype didn't increase the risk of endometrial cancer(OR=1.623,95% CI:0.720~3.659,P =0.243).[Conclusion]Among Han women from northeast China,the rs1059234 polymorphism of p21 gene is not associated with the risk of endometrial cancer.
2014, Vol. 31 
