Abstract：[Objective]To explore the risk factors of early diabetic nephropathy(EDN)in type 2 diabetes mellitus(T2DM)in order to provide the scientific evidence for early prevention and treatment of type 2 diabetic nephropathy (DN).[Methods]According to 24h urinary albumin level,566 T2DM patients were divided into EDN group(EN group,urinary albumin was 30~300mg/24h)and simple T2DM group(DM group,urinary albumin<30mg/24 h).The history of hypertension,fatty liver disease and smoking,the duration of diabetes mellitus,body mass index(BMI),triglyceride(TG),total cholesterol(TC),high density lipoprotein cholester-ol(HDL-C),low density lipoprotein cholesterol(LDL-C),uric acid(UA),glucosylated hemoglobin(HBA1C), fasting C-peptide(FCP),half an hour C-peptide(0.5hPCP)and 2 hour C-peptide(2hPCP)were compared be-tween two groups.[Results]There were significant differences in duration,the percentage of hypertension , the percentage of smoking,BMI,HDL-C,TG and UA levels between EN group and DM group(P<0.05), but there was no significant difference in the incidence of fatty liver disease,HBA1C,FCP,0.5hPCP,2hPCP and LDL-C between two groups(P>0.05).The duration,BMI,TG and UA in EN group were lower.Lo-gistical regression analysis showed that the duration of diabetes mellitus,the hypertension,high BMI and high LDL-C were the influencing factors of DN.[Conclusion]Long duration of diabetes mellitus,hypertension, high BMI and high LDL-C are the risk factors of EDN.Diabetic patients should stop smoking,strictly control blood pressure,blood sugar and body weight,regularly monitor UA and blood lipids and actively correct lipid metabolism disorders in order to prevent the occurrence and development of DN.
2014, Vol. 31 
