Abstract：[Objective]To explore the expression of activated leukocyte cell adhesion molecule(ALCAM), matrix metalloproteinase-1(MMP-1)and matrix metalloproteinase-9(MMP-9)in human meningioma and its clinical significance.[Methods]A total of 80 patients with meningioma were analyzed retrospectively.Accord-ing to the pathology,all patients were divided into non-invasion group(n=44)and invasion group(n=36). Immunohistochemical method was used to detect the expression of ALCAM,MMP-1 and MMP-9 after opera-tion.[Results]The expressions of ALCAM,MMP-1 and MMP-9 in invasion group were higher than those in non-invasion group(P<0.01).There was correlation among the expressions of ALCAM,MMP-1 and MMP-9 in invasive meningioma.[Conclusion]ALCAM,MMP-1 and MMP-9 are correlated with the invasiveness of meningioma and can be used as the auxiliary indexes for evaluating the invasiveness and prognosis of meningio-ma.Immunohistochemical examination can determine the potential invasiveness of meningioma,guide clinical treatment and improve clinical efficacy.
引用本文:
张爱华%何强华%王松青. 白细胞活化黏附因子和基质金属蛋白酶与脑膜瘤侵袭性的相关研究[J]. 医学临床研究, 2014, 31(5): 945-947.
ZHANG Ai-hua%HE Qiang-hua%WANG Song-qing. Study on the Correlation of Activated Leukocyte Cell Adhesion Molecule and Matrix Metallopro-teinases with Invasiveness of Meningiomas. 医学临床研究, 2014, 31(5): 945-947.
2014, Vol. 31 
