Abstract：[Objective]To evaluate clinical efficacy of zoledronic acid for the treatment of elderly male pa-tients with primary osteoporosis.[Methods]A total of 76 male patients with primary osteoporosis were ran-domly divided into 2 groups.The control group(n=39)was supplemented with calcium and vitamin D daily, while the treatment group(n=37)was given an intravenous drip infusion of zoledronic acid 5mg once based on the treatment of control group.The changes of bone mineral density and bone metabolism markers of all pa-tients were observed after 1 2 months of follow up.[Results]Bone mineral density of lumbar spine,total hip and femoral neck in treatment group was significantly higher than that in control group.Serum levels of bone metabolism markers such asβ-C-terminal telopeptide of type I collagen(β-CTx),procollagen type I N-terminal propeptide(PINP)and bone-specific alkaline phosphatase(BSAP)in treatment group were significantly lower than those in control group(P<0.05).The incidence of severe adverse reaction in two groups were 24.32%and 23.08% respectively,but there was no significant difference(P >0.05).[Conclusion]Zoledronic acid treatment for 1 year can markedly increase bone mineral density,decrease serum levels of bone metabolism markers and reduce the risk of fracture in elderly male patients with primary osteoporosis.
引用本文:
熊茂强%陈宇%罗展标. 唑来膦酸治疗老年男性原发性骨质疏松的临床效果评估[J]. 医学临床研究, 2014, 31(5): 859-862.
XIONGMao-qiang%CHENYu%LUOZhan-biao. Assessment of Clinical Efficacy of Zoledronic Acid for the Treatment of Elderly Male Patients with Primary Osteoporosis. 医学临床研究, 2014, 31(5): 859-862.
2014, Vol. 31 
