Abstract：[Objective] To observe the effect of remote ischemic preconditioning (RIPer) for protecting the liver of patients undergoing valve replacement surgery .[Methods] Totally 40 patients scheduled for selective valve re-placement surgery under cardiopulmonary bypass were randomly divided into remote ischemic preconditioning is-chemic group(RIPer group ,n =20) and control group(group C ,n = 20) .Before anesthesia ,cuff-inflator was placed on lower left limb of patients .RIPer group was treated with three circles of 5-minute ischemia and 5-minute reperfusion for lower left limb immediately at the clamping of aorta ..Group C group was not treated .Carotid ve-nous blood was collected before anesthesia induction (d0 ) ,d1 ,d3 and d7 after operation .Serum alamine transami-nase(ALT) ,glutamate transaminase(AST) ,total bilirubin(TBIL) and total bile acid(TBA) were measured .Su-peroxide dismutase(SOD) activity 24h before and after RIPer .[Results]Serum ALT and AST in two groups after operation were increased in different degree .ALT level in RIPer group at d1 ,d3 and d7 after operation was lower than that in group C ( P <0 .05) .AST level in RIPer group at d2 and d3 after operation was lower than that in group C( P <0 .05) ,but there was no significant difference in AST level at d7 between two groups( P >0 .05) . There was no significant difference in TBIL and TBA level at d1 ,d3 and d7 after operation between two groups . Plasma SOD activity in RIPer group 24h after RIPer was obviously higher than that in control group .[Conclusion]RIPer can reduce acute liver injury after cardiopulmonary bypass ,but has little impact on liver reserve function . SOD might participate in the protective effect of RIPer .
2014, Vol. 31 
