Abstract：[Objective]To explore the serum levels of protein tyrosine phosphatase 1B(PTP1B) ,leptin and adiponectin in patients with secondary amenorrhea .[Methods]A total of 60 patients diagnosed as secondary a-menorrhea in second affiliated hospital of Harbin medical university including 30 patients with obesity and 30 patients without obesity were selected as case group .Other 60 patients with normal menstrual including 30 pa-tients with obesity and 30 patients without obesity were selected as control group .Serum levels of PTP1B , leptin and adiponectin were measured by enzyme linked immunosorbent assay (ELISA) .[Results]Serum levels of PTP1B and leptin in amenorrhea with obesity group were (86 .24 ± 17 .58)ng/L and (16 .14 ± 2 .67)ng/L re-spectively ,which were obviously higher than those in patients with obesity in control group [(54 .66 ± 13 .27) ng/L and (10 .10 ± 1 .93)ng/L ,respectively)](all P <0 .05) ,while serum level of adiponectin was obviously lower than that of patients with obesity in control group [(4 .71 ± 2 .64)mg/L vs .(10 .26 ± 3 .13)mg/L]( P<0 .05) .There was no significant difference in serum level of PTP1B between amenorrhea with obesity group and amenorrhea without obesity group[(73 .97 ± 10 .25)ng/L]( P>0 .05) ,while serum level of leptin was ob-viously increased[(6 .53 ± 3 .25) ng/L] and serum level of adiponectin was obviously decreased[(11 .76 ± 3 .58) mg/L](all P<0 .05) .Serum levels of leptin and adiponectin were related with obesity .PTP1B in amenorrhea with obesity patients was positively correlated with body mass index (BMI) and leptin ,but negatively correla-ted with adiponectin .[Conclusion] Serum levels of PTP1B ,leptin and adiponectin in obesity patients with a-menorrhea are of vital significance in promoting the occurrence and development of the disease .
2014, Vol. 31 
