摘要【目的】探讨季节性变应性鼻炎（SAR）与血清白三烯E4（LTE4）及肿瘤坏死因子（TNF-α）水平的变化及临床意义。【方法】选择符合S A R标准的患者40例作为观察组，同时选取40例正常人作为对照组，分别在春、夏、秋、冬四个季节进行一次血清LTE4、TNF-α水平的检测。【结果】观察组血清LTE4、TNF-α水平在春、冬季较对照组均有显著增高，且两组相比较差异均有显著性（P＜0．01或 P＜0．05），而两组在夏、秋季血清LTE4、TNF-α水平相比较无统计学意义（P＞0．05）。且血清LTE4与TNF-α无明显相关性。【结论】血清LTE4、TNF-α通过参与局部炎症反应，在SAR发病过程中起到较重要的作用，在临床的预防及诊治中有较大的参考价值。
Abstract：[Objective] To explore changes and clinical significance of leukotriene E 4(LTE4) and tumor necrosis factor-alpha(TNF-α) in seasonal allergic rhinitis(SAR) .[Methods] Totally 40 patients who met the SAR diagnosis standard were regarded as observation group ,while 40 healthy people were regarded as control group .Serum levels of LTE4 and TNF-αin each season were detected .[Results]Compared with control group ,serum levels of LTE4 and TNF-αof observation group in spring and winter were increased significantly (LTE4:P <0 .05 in spring and P <0 .01 in winter)(TNF-α:all P <0 .01 in spring and winter) .There was no significant difference in serum levels of LTE4 and TNF-αin summer and autumn between two groups ( P>0 .05) .Serum LTE4 had no obvious correlation with TNF-α.[Conclusion] Serum levels of LTE4 and TNF-α play an important role in the pathogenesis of SAR through local inflammatory response .They are of great reference value in clinical prevention and treatment .
2014, Vol. 31 
