Abstract：[Objective] To explore the effect of statins on the prognosis of diabetic (DM ) patients with se-vere infection .[Methods] Totally 210 patients with DM and severe infection in endocrinology department and intensive care unit(ICU) department of Zhaogezhuang hospital of Kailuan general hospital from July 2011 to July 2013 were selected .All patients were randomly divided into simvastatin group (group T ) and control group(group T ) with 105 patients in each group .Patients in two groups were given the treatment of primary disease ,anti-infection ,nutrition and symptomatic support therapy .On the basis of above treatment ,group T was given oral or nasal simvastatin 40mg from the day of enrollment for 14 days .Acute physiological and chro-nic health score , levels of CRP , TNF-α, IL-6 , IL-10 , the incidence of multiple organ dysfunction score (MODS) and 28d fatality rate in two groups before(T1 ) ,4 d(T2 ) and 7 d(T3 ) after medication were measured and compared .[Results] The levels of IL-6 ,TNF-αand CRP in group T at T2 and T3 were lower than those in group T at T1 and in group C at T2 and T3 ( P<0 .05) ,and the levels of IL-10 were higher than those in group T at T1 and group C at T2 and T3 ( P<0 .05) .The levels of IL-6 ,TNF-αand CRP in group C at T3 were low-er than those at T1 ( P <0 .05) ,but the levels of IL-10 were higher than those at T1 ( P <0 .05) .The inci-dence of MODS in group T at T3 was 8 .57% ,which was obviously lower than that in group C(35 .23% )( P<0 .01) .The 28d fatality rate in group T at T3 was lower than that in group C(3 .81% vs .17 .14% )( P <0 .05) .[Conclusion] Statins for the treatment of DM patients with severe infection can decrease inflammatory response ,reduce the incidence of MODS and the 28d fatality rate and further improve the prognosis of pa-tients .Therefore they have certain clinical application value .
2014, Vol. 31 
