Clinical Diagnostic Value of Routine Blood Test-Related Indicators in Hepatitis, Cirrhosis, and Hepatocellular Carcinoma Associated with HCV Infection
LI Yang, TANG Dongli
Department of Laboratory Medicine, the First Affiliated Hospital of Zhengzhou University / Henan Provincial Key Laboratory of Laboratory Medicine, Zhengzhou Henan 450052
Abstract：【Objective】 To investigate the auxiliary diagnostic value of routine blood test-related indicators in the progression of chronic liver diseases (hepatitis, cirrhosis, hepatocellular carcinoma) associated with hepatitis C virus (HCV) infection.【Methods】 A total of 215 patients with HCV infection were enrolled and divided into the hepatitis group (60 cases), the cirrhosis group (95 cases), and the hepatocellular carcinoma group (60 cases) according to disease stage. Differences in routine blood test-related indicators were compared among the three groups. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy of individual and combined indicators for disease staging.【Results】 Significant differences (all P<0.05) were observed among the three groups in platelet count (PLT), plateletcrit (PCT), lymphocyte count (L), neutrophil count (N), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-neutrophil ratio (PNR). The combined detection of L + PLT + PNR improved diagnostic performance in distinguishing hepatitis from cirrhosis, while N + PCT enhanced sensitivity in differentiating cirrhosis from hepatocellular carcinoma.【Conclusion】 Routine blood test-related indicators provide important reference value for staging diagnosis of HCV-associated liver diseases. Combined testing can optimize differential diagnosis of hepatitis, cirrhosis, and hepatocellular carcinoma in HCV-infected patients, offering a simple and cost-effective laboratory basis for clinical practice.
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2025, Vol. 42 
