半夏泻心汤对萎缩性胃炎患者TLR4/NF-κB信号通路的影响

doi:10.3969/j.issn.1671-7171.2025.10.010

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摘要【目的】探讨半夏泻心汤对萎缩性胃炎患者Toll样受体4(TLR4)/核转录因子-κB(NF-κB)信号通路的影响。【方法】104例萎缩性胃炎患者,随机分为两组,每组52例。对照组给予常规西药治疗,观察组在对照组基础上联合半夏泻心汤治疗。比较两组临床疗效、中医证候积分、免疫功能指标、TLR4/NF-κB信号通路相关指标表达情况、炎症因子[白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]及不良反应发生情况。【结果】观察组总有效率高于对照组(P<0.05)。治疗后,两组中医证候各项积分低于治疗前(P<0.05),且观察组低于对照组(P<0.05);两组CD3⁺、CD4⁺较治疗前升高,CD8⁺降低(P<0.05),且观察组免疫功能各指标较对照组改善更明显(P<0.05);两组TLR4 mRNA、NF-κB mRNA表达及IL-2、IL-6、TNF-α均低于治疗前,且观察组低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】应用半夏泻心汤治疗萎缩性胃炎患者,不仅能提高临床疗效,改善患者中医证候和免疫功能指标,还能通过调节患者TLR4/NF-κB信号通路来减轻其炎症反应,且安全性较高。

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	江山

关键词 ：胃炎, 萎缩性, 中医药疗法, Toll样受体4, 信号传导, 治疗结果

Abstract：【Objective】To investigate the therapeutic effect of Banxia Xiexin Decoction on atrophic gastritis (CAG) by regulating the Toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling pathway.【Methods】 A total of 104 patients with CAG were randomly divided into two groups, with 52 cases in each. The control group received conventional Western medicine treatment, while the observation group received Banxia Xiexin Decoction in addition to the treatment used in the control group. The two groups were compared in terms of clinical efficacy, traditional Chinese medicine (TCM) symptom scores, immune function indicators, expression levels of the TLR4/NF-κB signaling pathway, inflammatory factors [interleukin-2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α)], and incidence of adverse reactions.【Results】The total effective rate in the observation group was significantly higher than that in the control group (P<0.05). After treatment, TCM symptom scores in both groups were significantly reduced compared to before treatment (P<0.05), with lower TCM scores observed in the observation group than in the control group (P<0.05). CD3⁺ and CD4⁺ levels increased and CD8⁺ levels decreased in both groups after treatment (P<0.05), with more pronounced improvement in immune function indicators in the observation group (P<0.05). Expression levels of TLR4 mRNA, NF-κB mRNA, and IL-2, IL-6, TNF-α were lower in both groups post-treatment compared to pre-treatment levels, with the observation group showing greater reductions than the control group (P<0.05). The difference in the overall incidence of adverse reactions between the two groups was not statistically significant (P>0.05).【Conclusion】 Banxia Xiexin Decoction in the treatment of CAG patients can significantly improve the clinical effective rate, TCM symptom scores, and immune function indicators. It also effectively alleviates inflammatory responses by regulating the expression of the TLR4/NF-κB signaling pathway, with a high level of safety.

Key words： Gastritis, Atrophic Traditional Chinese Medicine Therapy Toll-Like Receptor 4 Signal Transduction Treatment Outcome

收稿日期: 2024-05-27

中图分类号:

R573.32

引用本文:

江山. 半夏泻心汤对萎缩性胃炎患者TLR4/NF-κB信号通路的影响[J]. 医学临床研究, 2025, 42(10): 1714-1717.
JIANG Shan. Therapeutic Effect of Banxia Xiexin Decoction on Atrophic Gastritis via Regulation of the TLR4/NF-κB Signaling Pathway. JOURNAL OF CLINICAL RESEARCH, 2025, 42(10): 1714-1717.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.10.010 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I10/1714

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